Trainee Projects

This study aims to evaluate and modify the sexual pain items in the Endometriosis Pain Questionnaire (EPQ). The goal is to include the updated items in the next revision of the EPQ by the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project working group.  A qualitative approach will be used. Women with endometriosis and dyspareunia will be interviewed to identify important characteristics of their sexual pain and collect feedback about EPQ questions that measure dyspareunia. Next, information from the interviews will be used to select, adapt and/or create questions for the sexual pain section of the EPQ

Contact Kate Wahl for more information.

The purpose of this studys is to explore the role of psychological factors and central sensitization in deep dyspareunia in women with endometriosis. Participants complete history, pain, psycho-social and quality of life questionnaires as well as quantitative sensory testing using an algometer to measure pain pressure threshold. The hypothesis suggests that an increase in central sensitization will be associated with more severe deep dyspareunia. This may help identify women for whom standard hormonal or surgical treatment of endometriosis is not sufficient, and who may respond to multidisciplinary care.

We are currently recruiting controls!

Contact Natasha Orr for more information.

This study hypothesizes that nerve fibre density, nerve growth factor and mast cells are associated with pain symptoms in endometriosis.  The study includes a retrospective chart review for patients who have undergone surgical excision for endometriosis and immunohistochemistry experiments.

Dyspareunia is pain with penetration during sexual activity.1 Two common types of dyspareunia are superficial (pain upon initial entry of the vagina) and deep (pain associated with deep vaginal penetration). One of the main causes of deep dyspareunia is endometriosis, which is the growth of endometrial tissue outside of the uterus. Endometriosis is a chronic gynaecological disease that affects an estimated 10% of reproductive aged women.4,5 Deep dyspareunia may greatly impact the sexual quality-of-life (SQoL), such as sexual functioning or satisfaction, in women with endometriosis. Using data from 277 women in the Endometriosis Pelvic Pain Interdisciplinary Cohort (EPPIC) Data Registry, this study aims to determine if deep dyspareunia was associated with sexual quality-of-life in women with endometriosis independent of potential confounders.

This study involves immunohistochemistry analysis of archival histological endometriosis tissue and clinical information from our Endometriosis Pelvic Pain Interdisciplinary Cohort Data Registry.  Our hypothesis is that exposure to IL-1β and NGF can induce neuronal differentiations of PC12 cells and endometriotic stroma cells in co-culture system. Also, IL-1β and PA system members can promote cell migration and invasion in DIE. In addition, immunohistochemical expression of IL-1β, NGF, uPA and uPAR will be higher in DIE patients and associated with pain.